How Neurofolin works

Neurofolin works by supporting the production of natural, mood-regulating chemicals that assist with normal psychological function. Watch this one and a half minute video to understand more.

Further Reading

  1. Martone G. Enhancement of recovery from mental illness with L-methylfolate supplementation. Review article. Perspectives in Psychiatric care. 2017;1-4.
  2. Papakostas GI et al. L-methylfolate as adjunctive therapy for SSRI resistant major depression: results of two randomised, double-blind, parallel-sequential trials. The American Journal Psychiatry. 2012;169(12):1267-1274. 
  3. Zajecka JM et al. Long-Term Efficacy, Safety, and Tolerability of l-Methylfolate Calcium 15 mg as adjunctive therapy with Selective Serotonin Reuptake Inhibitors:A 12 month, open-Label study following a placebo-controlled acute study. Journal of Clinical Psychiatry 2016; 77:5.
  4. Ginsberg LD, Oubre AY, Daoud YA. L-methylfolate plus SSRI or SNRI from treatment initiation compared to SSRI or SNRI monotherapy in a major depressive episode. Innovation in Clinical Neuroscience. 2011; 8(1):19-28. 
  5. Bender A, Hagan K & Kingston N. The association of folate and depression: A meta-analysis. Journal of Psychiatric Research. 2017;95:8-18.
  6. Scaglione F & Panzavolta G.  Folate, folic acid and 5-methyltetrahydrofolate are not the same thing.  Xenobiotica. 2014;44:5, 480-488.
  7. Gilbody S, Lewis S & Lightfoot T. Human Genome Epidemiology (HuGE) Review. Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric disorders: A HuGE review. Am J Epidemiology. 2007;165:1–13.
  8. Stahl SM. L-Methylfolate: A vitamin for your monoamines. Journal of Clinical Psychiatry. 2008;69(9):1352-1353.
  9. Young SN. Folate and depression - a neglected problem. Journal of Psychiatry and Neuroscience. 2007;32(2):80-82. 
  10. Barchas JD, Altemus M. Monoamine hypotheses of mood disorders. In: Siegel GJ, Agranoff BW et al. Basic neurochemistry: molecular, cellular and medical aspects. 6th edition. Philadelphia: Lippincott-Raven; 1999. 
  11. Farah A. The role of L-Methylfolate in depressive disorders. CNS Spectrums: International Journal of Neuropsychiatric Medicine. 2009;14(1 suppl 2):2-7.